Abnormal cytogenetics in MM correlates with increased conversion from negative to positive MRD. MRD conversions were significantly more frequent for patients with any abnormality detected within the tumor including del17p, t(1:22), t(11:14)), hypodiploidy, or hyperdiploidy compared with those with normal tumor cytogenetics (hazard ratio [HR], 1.4; 95% confidence interval [CI], 1.1-1.8; P = .002). Upper and lower bands represent 95% CI.