Transcriptional profile of the NK^imm-cell repertoire: dysregulation of the proliferation and apoptosis machinery. RNA sequencing of the NK-cell compartment. (A) There were 152 DE genes in the HD and NK^imm groups combined (105 upregulated and 47 downregulated) and 107 DE genes in the NP and NK^imm groups combined (62 upregulated and 45 downregulated) after filtering for log₂ FC > 1.2. (B) Venn diagram displaying the shared DE genes between NK^imm/HD and NK^imm/NP groups. (C) Topology and content of the protein-protein interaction network driven by shared DE genes in CD56⁺ NK cells of the NK^imm group. (D) Heat maps illustrating median log₂-fold change in expression of NK^imm-unique genes identified by cross-referencing shared DE genes in panel B to DE genes in HD NK cell/CD56^bright NK-cell controls. (E) Query of NK^imm-unique seeds and related nodes (blue) in the PPI network that, when identified in GO biological processes are highlighted (teal). HD (n = 4), NP (n = 8), and NK^imm (n = 7). DE, differentially expressed.