Plasma protein profile in NK^imm group suggests cell turnover, apoptosis, and immune regulation. Analysis of 249 plasma proteins by proximity extension assay (Olink). (A-C) Levels of 39 proteins differed significantly in the NK^imm group compared with the HD group (nonparametric testing, Benjamini-Hochberg false discovery rate <.05) of which 22 were NK^imm unique and 17 were shared with the NP group. (D) Raw normalized protein expression values for selected proteins. (E) Topology and content of the protein-protein interaction network driven by significant plasma proteins (seeds) in the NK^imm group. (F) Query of NK^imm-unique seeds and related nodes (blue) in the PPI network, that, when identified in Gene Ontology (Biological Processes), are highlighted (teal). (G) Spearman rank correlations for NK^imm-defining parameters and plasma protein data for the 22 uniquely altered proteins in this group. (H) Raw plots for top correlating proteins. HD (n = 19-20), NP (n = 36-38), and NK^imm (n = 14). Data in the heat maps in panels B and C are depicted as absolute change in median compared with the HD median. *P < .05; **P < .01; ***P < .001; ****P < .0001, by nonparametric test.