Proposed mechanisms of crosstalk between MSPCs and HSCs downstream of Wnt5a-CDC42–dependent actin organization. MSPC cytoskeletal polarity facilitates cell contact–dependent HSC orientation and bidirectional tunneling nanotube-mediated transfer of ROS and mitochondria. Cytoskeleton-dependent secretory autophagy contributes to the MSPC secretome, in part regulating release of freely secreted HSC-supportive factors, extracellular vesicles, and vesicle-bound mitochondria. Professional illustration by Somersault 18:24.