Trauma and shock are associated with changes in coagulation parameters. Mice were subjected to both trauma and shock (TS). Control baseline (BL) mice were catheterized but were not subjected to trauma or shock (supplemental Figure 1). Plasma samples were collected 60 minutes after trauma and shock. Shown are the plasma activity levels of (A) FV (n = 6-7), (B) FVIII (n = 5), (C) fibrinogen (n = 3-6), (D) FII (n = 4-5), and (E) FX (n = 5). Results are shown as mean ± SD. Statistical significance was determined by 1-way ANOVA with Dunnett’s multiple comparisons test. **P < .01; ****P < .0001; ns, not significant.