Correction of coagulation parameters with ^superFVa after trauma and shock–induced ATC. Mice were subjected to both trauma and shock (TS). Control baseline (BL) mice were catheterized but were not subjected to trauma or shock (supplemental Figure 1). ^superFVa (SFVa) therapy (0.4 or 0.8 mg/kg) or saline control (0 mg/kg SFVa) was initiated 30 minutes after the induction of trauma and shock and administered as a continuous infusion at a rate of 5 µL/min for 20 minutes. Plasma samples were collected 60 minutes after trauma and shock. Shown are (A) APTT (n = 4-8), the plasma activity levels of (B) FV (n = 4-6), (C) FVIII (n = 5), and (D) fibrinogen (n = 3-6), (E) plasma TAT levels (n = 5-7), and (F) APC plasma levels (n = 5-10). Results are shown as mean ± SD. Statistical significance was determined by (A) Mann-Whitney test and (B-F) 1-way ANOVA with Dunnett’s multiple comparisons test. ***P < .001; ****P < .0001; ns, not significant.