Invariant genomic features driving each genomic group. Bar plots representing the mutational profiles of GC-1 (A), GC-2 (B), GC-3 (C), and GC-4 (D) and their importance. Red asterisks represent the most important genomic features based on an arbitrary importance cutoff of a mean decrease in accuracy ≥0.01. In addition, circos diagrams showing the pairwise cooccurrence of mutations in all GCs are illustrated to the right of the bar graphs. The colors of circos diagrams correspond to the GCs. The percentage of a cooccurrence between first and second gene mutations is represented by the color intensity of the ribbon connecting both genes.