Myeloma cells uptake long-chain FFAs through FATPs. (A) Expression of FATP isoforms in human myeloma cell lines from the Cancer Cell Line Encyclopedia and the ONCOMINE resources. (B) FATP relative mRNA expression in MM cell line used in our experiments. (C) Flow cytometric profile of FATP1 and FATP4 from CD138⁺ cells, CD138neg B cells, and T cells in patients with NDMM and RRMM. (D) Cell surface and intracellular expression of FATP1 and FATP4 from MM.1S, 5TGM1, OPM2, and KMS12PE MM cells using flow cytometry. (E) Reduction of labeled BODIPY C₁₂ and BODIPY C₁₆ uptake by 5TGM1 and OPM2 MM cells through blockade of FATPs by lipofermata treatment on MM cells. Data are presented as mean ± standard error of the mean. MFI, mean fluorescence intensity.