CONSORT diagram of study. Arm B included CLO in prephase. In this diagram, the 2 age groups (younger and older than 40 years of age) are combined (for CONSORT diagrams in subgroups, see supplemental Figures 1-3). Treatment protocols are detailed in supplemental Tables 1 and 2. In this figure, induction includes induction course and consolidation A and B for patients ≤40 years and remission induction 1 and consolidation 1 for patients >40 years of age. Consolidation 1 consists of intensification course 1A and 1B and remission induction course 2 for younger and older patients, respectively, and consolidation 2 contains interphase and intensification 2 for younger and consolidation 2 for older patients.