Immune profiling of pretreatment tumor samples by gene signatures. (A) Core tumor biopsy specimens (n = 18) were profiled by using the ∼1500-gene custom NanoString panel. Relative expression of signatures of 9 different immune cell subsets and tumor B cells are shown as heat map with samples ranked by CD8 Teff score. (B) ORR and CR rates stratified by CD8 Teff score. (C) PFS based on CD8 Teff score. FDC, follicular dendritic cell; NA, not assessable; PD, progressive disease; pDC, plasmacytoid dendritic cell; SD, stable disease; Teff, T-effector cell; TFH, T follicular helper cell; E, number of events; S, sample size.