Association between clone metrics and clinical phenotype. (A) Distribution of VAF of mutation patterns in premalignant conditions (including CHIP, unexplained anemia, clonal hematopoiesis, CH-AoE, and CCUS) (red) and MN (blue). (B) Association between VAF and myelodysplasia in distinct genotypes. For this analysis, a VAF cutoff of the mutation pattern under analysis was adopted that was associated with overt myelodysplasia with 90% specificity; that is, the VAF that was almost invariably associated with dysplasia.