Correlogram of biomarkers. Color corresponds to Pearson correlation value between biomarkers (after inverse normal transformation) as indicated in the color scale on the right (–1 to 1), with darker blue indicating stronger positive correlation (diagonals are darkest blue indicating correlation of 1 by definition) and darker red indicating stronger negative correlation. Only correlations with P < .01 are plotted. Biomarkers are ordered by hierarchical clustering using Ward’s D2 metric. The plot was constructed using the corrplot function from the R package corrplot. CA-9 indicates carbonic anhydrase 9; FOLR3, folate receptor γ; G-CSF, granulocyte colony-stimulating factor; GH, growth hormone; HB-EGF, heparin-binding EGF-like growth factor; hCG, human chorionic gonadotropin β; HER-2, human epidermal growth factor receptor 2; IL-1R1, interleukin-1 receptor type 1; ITAC, interferon-inducible T-cell α chemoattractant; MCP-4, monocyte chemotactic protein 4; MICA, MHC class I chain-related protein A; PARC, pulmonary and activation-regulated chemokine; SDF-1, stromal cell-derived factor-1; SOD-1, superoxide dismutase 1, soluble; TSH, thyroid-stimulating hormone.