Figure 3.
Histopathology of PEL and MCD. (A) PEL cells are large, with pleomorphic immunoblastic/plasmablastic features. A mitotic figure indicates proliferation of the tumor cells. Immunostaining of a cytospin preparation (insert) with an antibody to LANA shows the characteristic dot pattern in the nucleus (modified Giemsa stain, ×100 original magnification; insert: immunoperoxidase, ×100 original magnification). (B) Follicles in KSHV+ MCD are often involuted and hyalinized. There are many plasma cells in the interfollicular area and prominent vascular proliferation. In addition, a number of KSHV+ plasmablasts (arrows; insert) are present in mantle cell zones. These plasmablasts are LANA+ and vIL-6+ (hematoxylin and eosin [H&E] and immunoperoxidase staining, ×20 original magnification; inserts: ×60 original magnification).

Histopathology of PEL and MCD. (A) PEL cells are large, with pleomorphic immunoblastic/plasmablastic features. A mitotic figure indicates proliferation of the tumor cells. Immunostaining of a cytospin preparation (insert) with an antibody to LANA shows the characteristic dot pattern in the nucleus (modified Giemsa stain, ×100 original magnification; insert: immunoperoxidase, ×100 original magnification). (B) Follicles in KSHV+ MCD are often involuted and hyalinized. There are many plasma cells in the interfollicular area and prominent vascular proliferation. In addition, a number of KSHV+ plasmablasts (arrows; insert) are present in mantle cell zones. These plasmablasts are LANA+ and vIL-6+ (hematoxylin and eosin [H&E] and immunoperoxidase staining, ×20 original magnification; inserts: ×60 original magnification).

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