Mutation landscape of SMZL. (A) The heatmap shows genes mutated in ≥1% of SMZL cases. In the heatmap, each row represents a gene, and each column represents an SMZL case. The heatmap is manually clustered to emphasize mutational cooccurrence. The number and type of somatic mutations in any given gene are plotted in the histogram on the right of the heatmap. On the top of the heatmap are shown the cytogenetic and immunogenetic features for each SMZL sample. (B) The heatmap shows pairwise Pearson correlation coefficients between each pair of genes mutated in SMZL. Red cells indicate a positive correlation, blue cells indicate a negative correlation. (C) Pathways that are recurrently mutated in newly diagnosed SMZL. In the heatmap, rows correspond to genes, and columns represent individual patients. Color coding is based on gene alteration status (gray, wild type; red, mutated). The heat map was manually clustered to emphasize mutational cooccurrence.