MAZ is enriched at active TSSs and binds to DNA through a (G)₃C/A(G)₄ consensus site. (A) MAZ ChIP-seq enrichment profiles surrounding the HBA (top) and HBB (bottom) loci. (B) Genomic distribution of MAZ binding sites showing the number of peaks overlapping the category of genomic element indicated. (C) Heatmap plots of ATAC-seq, H3K4me3, H3K27ac, RNA Polymerase (PolII), and H3K27me3 signal in erythroblasts centered on MAZ peaks (sorted according to decreasing MAZ ChIP signal in erythroblasts). (D) PWMs of the enriched motifs (E-value < 0.01) in the training set of MAZ peaks (500 highest-ranked MAZ peaks) and their occurrence in all MAZ peaks. (E) Motif localization curves relative to the MAZ peak centers. The numbers of the enriched motifs correspond to the logos in (D). LCR, locus control region.