Probability of target attainment for various dosing schedules. The x-axis shows eculizumab dosing intervals ranged from 1 to 7 days. The y-axis shows the probability that the percent of target attainment would reach eculizumab the target trough concentration ≥100 μg/mL. The probability of target attainment was predicted for dosing protocols with different dose amount ranged from 300 to 2100 mg and are shown with different colored lines. PTA% close to 100% could be achieved by increasing the dose by 300 mg (1 vial) in each body weight cohort of protocol 4 (Figure 4).