siFga decreases the formation of pulmonary macrometastases in a model of experimental metastasis. Mice were injected with siLuc (red) or siFga (blue) weekly for 3 weeks prior to intravenous inoculation with GFP-expressing LLC cells (LLC^GFP), and blood and tissue were collected 14 days later. (A) Plasma fibrinogen concentrations were quantified by ELISA (n = 5). (B) Total pulmonary LLC^GFP metastases in mice treated with control siLuc or siFga (n = 10). (C) Total number of pulmonary LLC^GFP macrometastases (left) and micrometastses (right). (D) Representative images of lung lobes from siLuc- (left) and siFga- (right) treated mice. The cyan arrowheads indicate macrometastases, and the yellow arrows indicate micrometastases. *P < .05, **P < .01. ns, no significant difference. Error bars represent mean ± SEM.