RNA-sequencing of paired sTLR9-positive and sTLR9-negative samples revealed a striking gene set enrichment for lymphocyte activation, adhesion/migration, TLR signaling, and inflammation. (A) The top 10 overrepresented pathways in the differentially expressed gene list between the sTLR9-positive and sTLR9-negative samples. (B) Shows the differentially expressed genes in the TLR signaling pathway and the inflammation mediated by cytokine and chemokine signaling pathway. FDR, false discovery rate.