Effect of concurrent (mis)matching for the HLA-B leader and HLA-DRB1. (A) Overall survival. (B) Disease-free survival. (C) Relapse. (D) Transplant-related mortality. Probabilities are derived from multivariable models that adjusted for HLA-DPB1 mismatching. Survival model (A) was adjusted for comorbidities, disease type and status, recipient and donor age, recipient-donor cytomegalovirus match, time from diagnosis to transplant, HLA-DPB1, and stratified by graft type. Disease-free survival model (B) was adjusted for comorbidities, recipient age, recipient-donor cytomegalovirus match, donor relationship, and HLA-DPB1 and stratified by disease type and status. Relapse model (C) was adjusted for conditioning intensity and time from diagnosis to transplant and stratified by disease type and status. Transplant-related mortality model (D) was adjusted for comorbidities, conditioning intensity, disease type and status, recipient age, recipient-donor cytomegalovirus match, and recipient mean HLA-C surface expression.