Impact of clonal hematopoiesis on clinical outcome. (A) Kaplan-Meier analysis of OS stratified by CH status in the FIRE-3 cohort. (B) Kaplan-Meier analysis of OS stratified by DNMT3A mutation status in the FIRE-3 cohort. (C) Cox proportional hazard model of OS with CH status, treatment arm, liver-limited disease status, history of metastasis, ECOG performance status, and age as covariates. (D) Cox proportional hazard model of OS with CH-DNMT3A status, treatment arm, liver-limited disease status, history of metastasis, ECOG performance status, and age as covariates.