Survival curves for NRM mortality at 1 year stratified by high/low biomarker levels. Patients with high biomarker levels (red line) on day 14 post-HCT vs with those with levels below the cut-point (blue line); the cut-point based on Youden’s index was used for this analysis. In the training cohort, high levels of ST2, WFDC2, and TNFR1 were statistically significantly associated with NRM. In the validation cohort, high levels of 4 biomarkers predicted a statistically significant increase in NRM.