GWAS. (A) A GWAS was performed on blood CD34⁺ cell levels in 13 167 individuals, including 10 949 of Swedish ancestry and 2218 of non-Swedish European ancestry. The CD34⁺ level was defined as the number of CD34⁺ cells (red solid) divided by the number of CD45⁺ mononuclear cells (red dashed) (supplemental Figure 2). (B) In a combined analysis of the individuals of Swedish ancestry and the individuals of non-Swedish European ancestry, 9 significant and 2 suggestive (asterisks) associations (having P values within one order of magnitude from Bonferroni thresholds) were identified (supplemental Tables 5-8). The listed variants are the most significant (lead) variants for each association. Red bars indicate P values for association with blood CD34⁺ cell levels for the lead variants in the combined analysis. Blue bars indicate proportion of variance explained. Gene names indicate the likely candidate genes of each association. Genes were prioritized as candidate genes if they: (1) had a coding variant within the 99% credible set of probable causal variants (supplemental Table 9); (2) had a cis-eQTL in CD34⁺ cells (supplemental Table 10); or (3) the credible set contained a regulatory variant that maps either to the promoter or to a region with a chromatin looping interaction with the promoter in CD34⁺ cells. If none of these criteria were fulfilled, the closest gene was prioritized. The criterion used to call each gene a candidate gene is indicated by gray squares in the matrix. MAF, minor allele frequency.