Distribution of determined and predicted fludarabine AUC_T0−∞. Boxplots of the cumulative fludarabine AUC_T0−∞ determined in our cohort (determined) and predicted using a previously published population pharmacokinetic model taking renal function and body weight as covariates (predicted).¹⁷  Determined and predicted AUC_T0−∞ of every patient (n = 26) is linked with a black solid line. Groups were compared with the Mann-Whitney U test. P < .05 considered statistically significant.