Figure 1.
Impact of mobilization strategies on normal donor stem cell yield. Allogeneic donors were mobilized with cytokine (G-CSF or GM-CSF or G-CSF+GM-CSF), CXCR4 antagonists (Plerixafor or BL-8040) or combination of cytokine and CXCR4 antagonist (GM-CSF+Plerixfor). (A) Day 1 (of apheresis) CD34 stem cell yield per kg of recipient body weight in donors mobilized with different mobilization regimens. (B) Percentage of “poor mobilizer” (≤2 × 106 cells/kg), “less-than-optimal mobilizer” (2-5 × 106 cells/kg), and “good mobilizer” (≥5 × 106 cells/kg) in different mobilization regimens. (C) Day 1 peripheral blood (PB) CD34 cell count/μL in donors mobilized with different mobilization regimens. (D) Percentage of “poor mobilizer” (PB CD34 count ≤20/μL), “less-than-optimal” (PB CD34 count 20-40/μL), and “good mobilizer” (PB CD34 count ≥40/μL) in different mobilization regimens.