Multivariable analysis of factors associated with day-28 ANC and platelet counts. Forest plots of regression coefficients for day-28 neutrophil (A,C) or platelet (B,D) counts determined by high-dimensional inference for selected patient, disease, and treatment characteristics (A-B) or serum cytokine concentrations (C-D). Regression coefficient and associated 95% CI, denoted by circles and lines from a linear regression model, respectively. P-value of regression coefficient denoted by color gradient. CRS and ICANS variables are stratified by grade. Disease cohorts (CLL and NHL) and sex (female) are compared against a reference variable, ALL and male, respectively. All other variables are modeled as continuous variables. ALC, absolute lymphocyte count; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; PT, prothrombin time; PTT, partial thromboplastin time, TIM, T-cell immunoglobulin and mucin domain-containing protein; TNF, tumor necrosis factor; sTNFR, soluble TNF-receptor.