Mutational spectrum in patients with WM. (A) The total number of symptomatic patients with WM harboring ≥1 mutations in each gene. (B) The number of symptomatic patients with WM harboring mutations in 1, 2, and 3 different genes. (C) Co-mutation plot showing mutations present in all 258 patients: each column represents a single patient. The top row denotes the maximum VAF in each patient, with darker shades of pink indicating higher VAF. The bar graph on the right designates the proportion of the different mutation subtypes for each gene. OS (D) and PFS (E) among patients with WM with CH vs those without CH.