CH in patients with IgM MGUS and SWM. (A) Co-mutation plot showing mutations present in all 20 patients with IgM MGUS and patients with SWM: each column represents a single patient. The top row denotes the maximum VAF in each patient, with darker shades of pink indicating higher VAF. The bar graph on the right designates the proportion of the different mutation subtypes for each gene. PFS (B) and OS (C) among patients with IgM MGUS and those with SWM with CH vs those without CH. (D) Representative heat maps for the clonal dynamics of WM-related mutations and DTA mutations in WM. Values depicted in each square represent VAF. (E) Average change in VAF of DTA mutations assessed between consecutive time points, with or without intervening therapy.