Effect of mutation status (WT vs mutated) on overall response. (A) The bar graph summarizes the mutation frequency for genes analyzed in this study. The x-axis presents the number of patients with a mutation, and the y-axis presents a bar for the genes of interest. Red bars, Arm A; blue bars, Arm B. (B) The graph summarizes probabilities of overall response among patients stratified by mutation status. The x-axis presents the odds ratio (circles) with 80% CIs (error bars) for overall response, and the y-axis presents the genes of interest. Red circles and error bars, WT gene status; blue circles and error bars, mutated gene status.