Figure 4.
Changes in surface PD-L1 expression on BM cells during treatment. This plot represents the mean (circles) and 90% CIs (error bars) for surface PD-L1 (CD274) abundance (MESF) at screening and C3D22 on 3 different cell types: granulocytes, monocytes, and tumor blasts. PD-L1 is notably higher at C3D22 compared with screening on granulocytes and monocytes for patients in Arm A because the CIs are not overlapping. PD-L1 on tumor cells is not increased beyond the CI. Combo, combination therapy; Mono, monotherapy.