OS by cytogenetic risk category and individual high-risk lesion. (A) OS by cytogenetic risk category, defined as the time from infusion to date of death from any cause. (B) OS for KMT2A rearrangement compared with all others. (C) OS for Ph⁺ stratum compared with all others. (D) OS for Ph-like stratum compared with all others. (E) OS for infant leukemia with KMT2A rearrangement compared with all others.