Progression-free survival and exposure of CC-486 plus R-CHOP. (A) Kaplan-Meier curves of progression-free survival in the dose-escalation phase by dose (n = 14). (B) Mean plasma concentration time profiles of CC-486 with and without R-CHOP. Data are presented by dose. For cycle 1, day −6 dose administration, CC-486 was administered alone. For cycle 1, day 8 administration, CC-486 was given in combination with R-CHOP.