Myeloid cell–specific PKM2^−/− mice exhibit improved long-term sensorimotor recovery up to day 28. (A) Schematic of experimental design. (B) Left: representative magnetic resonance imaging from 1 mouse of each genotype on day 1 in filament model. White is the infarct area. Right: corrected mean infarct area of each genotype. (C) mNSS in the same mice at weeks 1, 2, 3, and 4 based on spontaneous activity, symmetry in the movement of 4 limbs, forepaw outstretching, climbing, body proprioception, and responses to vibrissae touch (higher score indicates a better outcome). Sensorimotor recovery in the same mice as analyzed by asymmetry index in cylinder test (D), fall latency in accelerated rota-rod test (E), motor strength in hanging-wire test (F), and right turn ratio in corner test (G). The data in panels C-G are in box plots and the horizontal bars indicate median value. The animals that successfully completed the particular neurologic test were included in the analysis (see exclusion/inclusion criteria in “Methods”). Data are mean ± SEM (B) or median ± range (C,G); n = 10 male mice (B,G). Data are from an unpaired Student t test (B) or 2-way repeated measures ANOVA (Kruskal-Wallis test) followed by Fisher’s LSD test (D,G).