Networks of differentially expressed plasma proteins in children with reduced hemoglobin. Comparison of differentially expressed plasma proteins in children with hemoglobin drop (A,B) with SMA and (C,D) without SMA to control malaria-infected children by Ingenuity Pathway Analysis. Analyses in panels A and C included differentially expressed proteins defined as log₂ fold change <−0.3 or >0.3, P < .05, and analyses displayed in panels B and D included differentially expressed proteins defined as log₂ fold change ≤-1.0 or ≥1.0. Green and red symbols represent proteins that were down- and upregulated, and gray symbols represent similarly expressed proteins identified in the study. Solid and broken lines represent direct and indirect interactions respectively. Proteins selected for validation study are marked with blue circles.