Treatment schema of the vemurafenib plus rituximab regimen. Schedule of vemurafenib plus rituximab used in the trial,³⁵ where, however, in no patients a third cycle was delivered. The 2-week interval after vemurafenib dosing in each cycle was to allow enough time for adequate normal bone marrow (BM) recovery following clearance of the leukemic cell infiltration (especially after the first cycle) and, thus, for optimal reading of the BM biopsy scheduled after each cycle; however, outside a trial, interim BM biopsies are not typically needed, and the 2-week interval might be omitted from each cycle.