Figure 1.
Characterization of the TAA-T product by phenotype and TCR clonotype diversity. (A) Variable composition of the TAA-T products by phenotype (CD8+, CD4+, NK [natural killer], TCRγδ [γ δ T cells], NKT [natural killer T cells]) presented as percent of total cells in product as determined by 12-color flow cytometry (n = 23). (B-C) Memory phenotype described as central memory (TCM; CD3+CD4/8+CD45RO+CCR7+CD62L+), effector memory (TEM; CD3+CD4/8+CD45RO+CCR7−CD62L−), and effector T cells (TEFF; CD3+CD4/8+CD45RO−CCR7−CD62L) for evaluable samples (n = 11). (D) Diversity of TCR sequences of TAA-T products shown for representative patients in the relapsed group (P9, P3) and patients treated preemptively with TAA-T products (P12, P13).