Whole-exome and transcriptome sequencing identified frequent deletions in PAX5, IKZF1, CDKN2A/B and mutations in epigenetic regulators in VNN2⁺patients. Whole-exome sequencing was performed in 27 VNN2⁺ patient samples (22 diagnosis, 5 relapse), and transcriptome sequencing was performed in 16 VNN2⁺ patient samples (13 diagnosis, 3 relapse). Details about sample selection are described in supplemental Figure 4. Sample identifiers are shown at the bottom of the figure. «V_a» indicates samples at diagnosis, and «V_c» indicates samples at relapse. Samples in which transcriptome sequencing was performed can be identified by an additional «_dx» or «_rz» at the end of the identifier. dx, diagnosis; rz, relapse.