Pretreatment ctDNA is associated with other prognostic variables. (A) Scatter plot shows the median pretreatment ctDNA for all patients and the relationship of pretreatment ctDNA in classic histology compared with blastoid histology. (B) Scatter plot shows pretreatment ctDNA across MIPI categories. (C) Scatter plot demonstrates the relationship of pretreatment ctDNA and the Ki67 proliferation index. (D) Spearman correlation of pretreatment ctDNA and SUV_max on baseline FDG-PET scan. (E) Spearman correlation of pretreatment ctDNA and TMTV on baseline FDG-PET scan. (F) Kaplan-Meier estimates of PFS in patients above the median (ctDNA high) compared with below the median (ctDNA low). *P < .05.