FVIII activity profiles and terminal VCN for individual animals administered an AAV-ET3 vector. Panels display FVIII activity over time and terminal VCN after administration of AAV-E06.TTR-ET3 (A-F) or AAV-HCB-ET3 (G-J). Each panel represents 1 vector/dose group, and each curve represents a single animal. Terminal VCN was quantified by qPCR on liver DNA. FVIII activity profiles for individual animals administered the AAV-HSQ vectors are shown in supplemental Figure 3.