General approach for posttransplantation immune-mediated hemolysis. The graph outlines underlying mechanisms of posttransplantation hemolysis, timing posttransplantation, preventive methods, and treatment strategies. Note there is no consensus or guideline on how to manage posttransplantation immune-mediated anemia. The management approaches listed are based on expert opinions and available literature. AIHA, autoimmune hemolytic anemia; IVIG, IV immunoglobulin; TPO, thrombopoietin.