PRCA. PRCA is more frequently encountered in major ABO mismatch during the first 1 to 3 months posttransplantation. Management approach is similar to PLS, with frequent monitoring and RBC transfusion support. Other pharmacologic interventions can be considered in refractory cases. CBC, complete blood count; Hb, hemoglobin; IVIG, IV immunoglobulin; TMA, thrombotic microangiopathy.