Genomic and transcriptome of malignant plasma cells from primary PCL compared with newly diagnosed multiple myeloma. (A) Incidence of main cytogenetics abnormalities and mutations in 90 primary PCL compared with 907 newly diagnosed MM, ***P < .0001, **P < .005. (B) Unsupervised clustering of 90 primary PCL and 288 newly diagnosed MM based on the expression levels of the 100 most variable genes. (C) Gene expression profiling comparing differentially expressed genes between primary PCL and newly diagnosed MM, with at least twofold change (P < .05, FDR<0.01). (D) GSEA from 90 primary PCL compared with 288 newly diagnosed MM.