HSCT-treated GC/JAK3 patients without immunoglobulin replacement therapy have a decrease in nasopharyngeal secretory IgA. (A) Serum immunoglobulin concentrations in healthy and HSCT-treated SCID patients. (B) Nasopharyngeal concentrations of total IgM, IgD, and IgG in healthy and HSCT-treated SCID patients. (C) Nasopharyngeal concentrations of total IgA and IgA1 and IgA2 in healthy and HSCT-treated SCID patients. (D) Nasopharyngeal concentrations of total IgE in healthy and HSCT-treated SCID patients. Panels A through D: box plots with median ± minimum to maximum. P values were determined with the Kruskal-Wallis test followed by Dunn’s posttest for multiple group comparisons; *P < .05, **P < .005, ***P < .001. n.s., not significant.