Process of SIPA clot formation in a large stenotic vessel. (1) Schematic showing the bottom half of a stenosed vessel. The dotted line indicates the axisymmetric centerline. VWF (brown) adsorption onto the collagen surface under high shear rate. (2) Sparce platelet adhesion (light blue) to the surface. (3) Details of the dotted box in panel 2. RPA begins and forms mountains and valleys of platelet aggregates. (4) SIPA accelerates the thrombus growth with higher shear rate near the apex. (5) Growing thrombus at the apex alters the flow environment and creates larger recirculation region downstream. (6) SIPA clot occludes the vessel. (7) Final SIPA clot (light gray) comparison between the schematic (left) and the experimental photograph (right).