Experiments revealing a role of HMGA1 in MPN progression. (A) Increased expression of HMGA1 in primary hematopoietic cells from patients with MPN progressing to MF and AML. (B) Hmga1^+/− mice developed a significantly milder disease phenotype than Hmga1^+/+JAK2^V617F transgenic mice. (C) Gene silencing studies revealed the existence of a GATA2-controlled transcriptional network involved in maintenance of a transformed phenotype of secondary JAK2^V617F+ AML cell lines (SET-2, DAMI). ET, essential thrombocytopenia; HSPC, hematopoietic stem and progenitor cell; mut, mutated; PV, polycythemia vera; sAML, secondary AML. Professional illustration by Somersault18:24.