Genetic mutations frequency and Kaplan-Meier estimates of overall survival. (A) Bar graph reporting the frequency of driver and nondriver genetic mutations among patients with PMF and SMF. (B-D) Kaplan-Meier estimates of overall survival (OS) in the entire series of patients with MF (B) or those with PMF (C) or SMF (D) separately, according to the 4-tier genomic classification (NGS) proposed by Luque Paz et al.⁵  (E-F) Kaplan-Meier estimates of OS in high-risk patients with PMF (E) and SMF (F) by the presence or absence of ASXL1^mut. *P < .1, **P < .001, ****P < .0001. DM, double mutated; TN, triple negative; WT, wild type.