Figure 2.
Performance of prognostic scoring systems. (A) Comparison of the prognostic performance among standard prognostic scoring systems (DIPSS for PMF and MYSEC-PM for SMF), their combinations with molecular scores (HMR and NGS), and novel integrated clinical-molecular score systems (MIPSS70 and MIPSS70plus version 2.0). For the purpose of the study, the HMR model included 3 genomic categories: patients with no mutations in HMR genes (ie, ASXL1, EZH2, SRSF2, IDH1 and IDH2, and U2AF1), patients with 1 HMR mutation, and patients with ≥2 HMR mutations. (B-C) Brier score for prediction of death measured over time for standard and integrated prognostic scoring systems in PMF (B) and SMF (C). (D-E) Time-dependent area under the curve (AUC) for prediction of death for standard and integrated prognostic scoring systems in PMF (D) and SMF (E).

Performance of prognostic scoring systems. (A) Comparison of the prognostic performance among standard prognostic scoring systems (DIPSS for PMF and MYSEC-PM for SMF), their combinations with molecular scores (HMR and NGS), and novel integrated clinical-molecular score systems (MIPSS70 and MIPSS70plus version 2.0). For the purpose of the study, the HMR model included 3 genomic categories: patients with no mutations in HMR genes (ie, ASXL1, EZH2, SRSF2, IDH1 and IDH2, and U2AF1), patients with 1 HMR mutation, and patients with ≥2 HMR mutations. (B-C) Brier score for prediction of death measured over time for standard and integrated prognostic scoring systems in PMF (B) and SMF (C). (D-E) Time-dependent area under the curve (AUC) for prediction of death for standard and integrated prognostic scoring systems in PMF (D) and SMF (E).

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