Increased transcriptional activity of TEAD TFs in SF3B1^K700E HSPCs. (A) TF motifs enriched in peaks more accessible in SF3B1^K700E compared with SF3B1^WT HSPCs and linked to upregulated genes. (B) Most statistically significant TF motifs enriched in peaks more accessible in SF3B1^K700E compared with SF3B1^WT HSPCs and linked to upregulated genes. (C) Tornado plots showing the normalized accessibility signal in peaks more accessible in SF3B1^K700E compared with SF3B1^WT HSPCs and linked to upregulated genes that contain TEAD motifs. (D) Expression levels of TEAD family genes in iPSC-HSPCs. Mean and SEM of transcripts per million (TPM) values from RNA-seq are shown. **P_adj ≤ .01; ***P_adj ≤ .001. (E) TEAD reporter activity in HSPCs from the indicated iPSC lines. Mean and SEM of 2 to 5 independent differentiation and transduction experiments per line are shown. n.s., not significant; **P ≤ .01.