Mutational characteristics of T and GD LGL leukemia subtypes. (A-B) Nonsilent mutation burden and affected gene counts in T and GD subtypes. (C) Euler diagram of genes that are mutated in at least 3 patients, sectioned by LGL subtypes. Genes that are mutated in 4 or more patients and are shared between T and GD-LGL (blue area) are labeled. (D-E) Single nucleotide variant class in the cohort and percent C>T mutation comparison in T and GD subtypes. (F-G) Microsatellite instability scores and SBS1 signature contributions in T and GD subtypes.