Oncoplot of putative drivers in LGL leukemia. (A) Seven different driver analysis tools identified 15 gene variants with putative driver roles present in at least 3 LGL leukemia samples. Each row represents 1 of the 15 putative drivers, whereas the columns represent individual patients. LGL disease cohorts are color coded at the top. Type of alteration in putative driver genes is indicated by the colored boxes, which are defined under “Alterations,” and gray indicates WT. The top bar graph shows the number of amplification and deletion events. Right bar graph shows the distribution of variants for a given gene across the 2 LGL cohorts. Bottom annotations represent clinical phenotypes of individual patients, with color definitions found in the rightmost annotation. ANC values above 1.5k/µl and HGB values above 12 are annotated as “Normal,” and anything below is “Low.” Treatment indicates if patients were on LGL treatment (methotrexate, cyclophosphamide, or cyclosporine) at the time of sample acquisition. Unknown values are colored in gray. (B) Kyoto Encyclopedia of Genes and Genomes pathway analysis of somatic mutations observed in the cohort using SLAPenrich. The size of the nodes represents the number of genes in the cohort observed in the pathway. The color of the nodes represents the percent of those genes that uniquely belong in each pathway. The thickness of the edges represents the Jaccard index between the nodes.