Significant co-occurrence of STAT3 with KMT2D or SETD1B mutations. (A) Comutation plot of all nonsilent mutations observed in the 105-patient LGL leukemia cohort. Numbers in brackets after gene names represent the number of mutations in this gene in the cohort. Significant pairs of genes were detected by pairwise Fisher’s exact test. (B-C) VAF density plots were used to infer clones or “clusters.” Each dot represents individual somatic variants observed in a given patient. The color of the dots represents inferred clusters. Colored annotations indicate different types of STAT3 mutations. (B) Four representative KMT2D VAF density plots. The first 2 demonstrate inclusion of both STAT3 and KMT2D in the same predicted clone. The following 2 plots demonstrate 2 mutations associating with 2 different clones. (C) VAF density plot of all patients harboring SETD1B mutations in the cohort.